AE-Bio　東京大学農学生命科学研究科　生産環境生物学専攻 close

嶋田 透


嶋田 透


生産・環境生物学専攻
昆虫遺伝研究室


教 授

　略　歴
1982年　東京大学農学部農業生物学科卒
1987年　東京大学大学院農学系研究科博士課程修了

　研究概要
　地球上に生息する約400万種の昆虫は、今から約4億年前に現れた一つの祖先生物から急速に分化して生じたものである。その間に、約2万個の遺伝子からなる昆虫のゲノムは、祖先から引き継いだ遺伝子を改造しただけでなく、新たな遺伝子を創出したり、途中で遺伝子を廃棄したりしてきた。現生昆虫の多様な形態と生態は、ゲノム構造とゲノム機能の種間差異が表現された結果である。私は、カイコをはじめとする鱗翅目の昆虫を材料にして、そこに特異的に見られる生物現象が、どのような遺伝子群の働きで実現しているのか、それを遺伝学、分子生物学、生化学、組織学などの手法によって解明している。具体的には「昆虫の性決定の遺伝子ネットワーク」「カイコゲノムの特異性の解明」「カイコの胚休眠の遺伝子機構」「細菌から鱗翅目昆虫へ水平移動した遺伝子の機能」「カイコゲノムに存在するレトロウイルス様因子」などを研究している。これらの研究は、生物学として重要であるだけでなく、昆虫ゲノムの特異性にもとづく選択的殺虫剤の開発や昆虫機能を利用した新技術の創出のためにも必要である。

　最近の研究成果（2006年〜2013年）
  1. Bisch-Knaden, S., Daimon, T., Shimada, T., Hansson, B. S., and Sachse, S. (2013) Anatomical and functional analysis of domestication effects on the olfactory system of the silkmoth Bombyx mori. Proc. Biol. Sci. 281: 20132582
  2. Suetsugu, Y., Futahashi, R., Kanamori, H., Kadono-Okuda, K., Sasanuma, S. I., Narukawa, J., Ajimura, M., Jouraku, A., Namiki, N., Shimomura, M., Sezutsu, H., Osanai-Futahashi, M., Suzuki, M. G., Daimon, T., Shinoda, T., Taniai, K., Asaoka, K., Niwa, R., Kawaoka, S., Katsuma, S., Tamura, T., Noda, H., Kasahara, M., Sugano, S., Suzuki, Y., Fujiwara, H., Kataoka, H., Arunkumar, K. P., Tomar, A., Nagaraju, J., Goldsmith, M. R., Feng, Q., Xia, Q., Yamamoto, K., Shimada, T., and Mita, K. (2013) Large scale full-length cDNA sequencing reveals a unique genomic landscape in a lepidopteran model insect, Bombyx mori. G3 (Bethesda) 3: 1481-1492.
  3. Shoji, K., Kiuchi, T., Hara, K., Kawamoto, M., Kawaoka, S., Arimura, S., Tsutsumi, N., Sugano, S., Suzuki, Y., Shimada, T., and Katsuma, S. (2013) Characterization of a novel chromodomain-containing gene from the silkworm, Bombyx mori. Gene 527: 649-654.
  4. Tabunoki, H., Ono, H., Ode, H., Ishikawa, K., Kawana, N., Banno, Y., Shimada, T., Nakamura, Y., Yamamoto, K., Satoh, J-I,. and Bono, H. (2013) Identification of key uric acid synthesis pathway in a unique mutant silkworm Bombyx mori model of Parkinson's disease. PLoS ONE 8: e69130.
  5. Hirayama, C., Ono, H., Meng, Y., Shimada, T., and Daimon, T. (2013) Flavonoids from the cocoon of Rondotia menciana. Phytochemistry 94: 108-112.
  6. Bono, F., De Smet, F., Herbert, C., De Bock, K., Georgiadou, M., Fons, P., Tjwa, M., Alcouffe, C., Ny, A., Bianciotto, M., Jonckx, B., Murakami, M., Lanahan, A., Michielsen, C., Sibrac, D., Dol-Gleizes, F., Mazzone, M., Zacchigna, S., Herault, J. P., Fischer, C., Rigon, P., Ruiz de Almodovar, C., Claes, F., Blanc, I., Poesen, K., Zhang, J., Segura, I., Gueguen, G., Bordes, M. F., Lambrechts, D., Broussy, R., van de Wouwer, M., Michaux, C., Shimada, T., Jean, I., Blacher, S., Noel, A., Motte, P., Rom, E., Rakic, J. M., Katsuma, S., Schaeffer, P., Yayon, A., Schepdael, V. A., Schwalbe, H., Gervasio, F., Carmeliet, G., Rozensky, J., Dewerchin, M., Simons, M., Christopoulos, A., Herbert, J. M., and Carmeliet, P. (2013) Inhibition of tumor angiogenesis and growth by a small-molecule multi-FGF receptor blocker with allosteric properties. Cancer Cell 23: 477-488.
  7. Wang, L., Kiuchi, T., Fujii, T., Daimon, T., Li, M., Banno, Y., Kikuta, S., Kikawada, T., Katsuma, S., and Shimada, T. (2013) Mutation of a novel ABC transporter gene is responsible for the failure to incorporate uric acid in the epidermis of ok mutants of the silkworm, Bombyx mori. Insect Biochem. Mol. Biol. 43: 562-571.
  8. Lin, Y., Meng, Y., Wang, Y.-X., Luo, J., Katsuma, S., Yang, C.-W., Banno, Y., Kusakabe, T., Shimada, T., and Xia, Q.-Y. (2013) Vitellogenin receptor mutation leads to the oogenesis mutant phenotype 'scanty vitellin' of the silkworm, Bombyx mori. J. Biol. Chem. 288: 13345-13355.
  9. Fujii, T., Abe, H., Kawamoto, M., Katsuma, S., Banno, Y., and Shimada, T. (2013) Albino (al) is a tetrahydrobiopterin (BH4)-deficient mutant of the silkworm Bombyx mori. Insect Biochem. Mol. Biol. 43: 594-600.
  10. Ishihara, G., Shimada, T., and Katsuma, S. (2013) Functional characterization of Bombyx mori nucleopolyhedrovirus CG30 protein. Virus Res. 174: 52-59.
  11. Tsuchida, A., Ishihara, G., Shimada, T., and Katsuma, S. (2013) Dimerization and proper degradation of Bombyx mori nucleopolyhedorivirus IE2 are required for efficient virus growth in B. mori larvae. Appl. Entomol. Zool. 48: 125-130.
  12. Wang, L., Kiuchi, T., Fujii, T., Daimon, T., Li, M., Banno, Y., Katsuma, S., and Shimada, T. (2013) Reduced expression of the dysbindin-like gene in the Bombyx mori ov mutant exhibiting mottled translucency of the larval skin. Genome 56: 101-108.
  13. Kawaoka, S.*, Hara, K.*, Shoji, K., Kobayashi, M., Shimada, T., Sugano, S., Tomari, Y., Suzuki, Y., and Katsuma, S. (2013) The comprehensive epigenome map of piRNA clusters. Nucleic Acids Res. 41:1581-1590. (* These authors contributed equally to this work.)
  14. Hori, T., Kiuchi, T., Shimada, T., Nagata, M., and Katsuma, S. (2013) Silkworm plasmatocytes are more resistant than other hemocyte morphotypes to Bombyx mori nucleopolyhedrovirus infection. J. Invertebr. Pathol. 112: 102-104.
  15. 阿部広明・藤井 告・三田和英・嶋田透（2012）カイコＷ染色体研究の歴史と最近の分子生物学的研究．（特集「カイコ染色体研究のトピックス」）．蚕糸・昆虫バイオテック．81（印刷中）．
  16. Katsuma, S. and Shimada, T. (2012) Comparative studies of Bombyx mori nucleopolyhedrovirus infection in BmN4 cell lines maintained in different laboratories. J. Insect Biotechnol. Sericol. 81: 7-12.
  17. Fujii, T., Banno, Y., Abe, H., Katsuma, S., and Shimada, T. (2012) A homolog of the human Hermansky-Pudluck Syndrome-5 (HPS5) gene is responsible for the oa larval translucent mutants in the silkworm, Bombyx mori. Genetica 140: 463-468.
  18. Daimon, T., Fujii, T., Fujii, T., Yokoyama, T., Katsuma, S., Shinoda, T., Shimada, T., and Ishikawa, Y. (2012), Reinvestigation of the sex pheromone of the wild silkmoth, Bombyx mandarina: The effects of bombykal and bombykyl acetate. J. Chem. Ecol. 38: 1031-1035.
  19. Ito, K., Kidokoro, K., Katsuma, S., Shimada, T., Yamamoto, K., Mita, K., and Kadono-Okuda, K. (2012) Positional cloning of a gene responsible for the cts mutation of the silkworm, Bombyx mori. Genome 55: 493-504.
  20. Katsuma, S., Koyano, Y., Kang, W.-K., Kokusho, R., Kamita, S. G., and Shimada, T. (2012) The baculovirus uses a captured host phosphatase to induce enhanced locomotory activity in host caterpillars. PLoS Pathogens 8: e1002644.
  21. Daimon, T., Kozaki, T., Niwa, R., Kobayashi, I., Furuta, K., Namiki, T., Uchino, K., Banno, Y., Katsuma, S., Tamura, T., Mita, K., Sezutsu, H., Nakayama, M., Itoyama, K., Shimada, T., and Shinoda, T. (2012) Precocious metamorphosis in the juvenile hormone-deficient mutant of the silkworm, Bombyx mori. PLoS Genet. 8: e1002486.
  22. Hara, K., Fujii, T., Suzuki, Y., Sugano, S., Shimada, T., Katsuma, S., and Kawaoka, S. (2012) Altered expression of testis-specific genes, piRNAs, and transposons in the silkworm ovary masculinized by a W chromosome mutation. BMC Genomics 13: 119.
  23. Kang, W.-K., Katsuma, S., Matsuda-Imai, N., Kurihara, M., Yoshiga, T., Shimada, T., and Matsumoto, .S. (2012) Identification and characterization of host factors interacting with Bombyx mori nucleopolyhedrovirus ORF8. J. Microbiol. 50: 469-477.
  24. Daimon, T.*, Fujii, T.*, Yago, M., Hsu, Y.-F., Nakajima, Y., Fujii, T., Katsuma, S., Ishikawa, Y., and Shimada, T. (2012) Female sex pheromone and male behavioral responses of the bombycid moth Trilocha varians: comparison with those of the domesticated silkmoth Bombyx mori. Naturwissenschaften 99: 207-215. (* These authors contributed equally to this work.)
  25. Katsuma, S., Kobayashi, J., Koyano, Y., Matsuda-Imai, N., Kang, W.-K., and Shimada, T. (2012) Baculovirus-encoded protein BV/ODV-E26 determines tissue tropism and virulence in lepidopteran insects. J. Virol. 86: 2545-2555.
  26. Iwanaga, M., Hitotsuyama, T., Katsuma, S., Ishihara, G., Daimon, T., Shimada, T., Imanishi, S., and Kawasaki, H. (2012) Infection study of Bombyx mori macula-like virus (BmMLV) using a BmMLV-negative cell line and an infectious cDNA clone. J. Virol. Methods 179: 316-324..
  27. Kawaoka, S.*, Mitsutake, H.*, Kiuchi, T., Kobayashi, M., Yoshikawa, M., Suzuki, Y., Sugano, S., Shimada, T., Kobayashi, J., Tomari, Y., and Katsuma, S. (2012) A role for transcription from a piRNA cluster in de novo piRNA production. RNA 18: 256-273. (* These authors contributed equally to this work)
  28. Daimon, T., Yago, M., Hsu, Y.-F., Fujii, T., Nakajima, Y., Kokusho, T., Abe, H., Katsuma, S., and Shimada, T. (2012) Molecular phylogeny, laboratory rearing, and karyotype of the bombycid moth, Trilocha varians. J. Insect Sci. 12: 49.
  29. 嶋田 透（2012）カイコとクワの結びつきの進化的起源．シルクだより ((財)大日本蚕糸会)．44: 7-9.
  30. Fujii, T., Abe, H., Yamamoto, K., Katsuma, S., and Shimada, T. (2011) Interspecies linkage analysis of mo, a Bombyx mori locus associated with mosaicism and gynandromorphism. Genetica 139: 1323-1329.
  31. Fujii, T., Fujii, T., Namiki, S., Abe, H., Sakurai, T., Ohnuma, A., Kanzaki, R., Katsuma, S., Ishikawa, Y., and Shimada, T. (2011) Sex-linked transcription factor involved in a shift of sex pheromone preference in the silkmoth, Bombyx mori. Proc. Natl. Acad. Sci. USA. 108: 18038-18043.
  32. Kawaoka, S., Kadota, K., Arai, Y., Suzuki, Y., Fujii, T., Abe, H., Yasukochi, Y., Mita, K., Sugano, S., Shimizu, K., Tomari, Y., Shimada, T., and Katsuma, S. (2011) The silkworm W chromosome is a source of female-enriched piRNAs. RNA 17: 2144-2151.
  33. Kokusho, R., Zhang, C.-X., Shimada, T., and Katsuma, S. (2011) Comparative analysis of budded virus infectivity of Bombyx mandarina and B. mori nucleopolyhedroviruses. Virus Genes 43: 313-317.
  34. Kawaoka. S., Arai, Y., Kadota, K., Suzuki, Y., Hara, K., Sugano, S., Shimizu, K., Tomari, Y., Shimada, T., and Katsuma, S. (2011) Zygotic amplification of secondary piRNAs during the silkworm embryogenesis. RNA 17: 1401-1407.
  35. Kiuchi, T., Banno, Y., Katsuma, S., and Shimada, T. (2011) Mutations in an amino acid transporter gene are responsible for sex-linked translucent larval skin of the silkworm, Bombyx mori. Insect Biochem. Mol. Biol. 41: 680-687.
  36. Fujii, T., Ito, K., Tatematsu, M., Shimada, T., Katsuma, S., and Ishikawa, Y. (2011) Sex pheromone desaturase functioning in a primitive Ostrinia moth is cryptically conserved in congeners' genomes. Proc. Natl. Acad. Sci. USA. 108: 7102-7106.
  37. Tabunoki, H., Ode, H., Banno, Y., Katsuma, S., Shimada, T., Mita, K., Yamamoto, K., Sato, R., Ishii-Nozawa, R., and Satoh J-I. (2011) BmDJ-1 is a key regulator for the developmental oxidative modification of the silkworm, Bombyx mori. PLoS ONE 6: e17683.
  38. Fujii, T., Abe, H., Katsuma, S., and Shimada, T. (2011) Identification and characterization of the fusion transcript, composed of the apterous homolog and a putative protein phosphatase gene, generated by 1.5-Mb interstitial deletion in the vestigial (Vg) mutant of Bombyx mori. Insect Biochem. Mol. Biol. 41:306-312.
  39. Tatematsu, K., Yamamoto, K., Uchino, K., Narukawa, J., Iizuka, T., Banno, Y., Katsuma, S., Shimada, T., Tamura, T., Sezutsu, H., and Daimon, T. (2011) Positional cloning of silkworm white egg 2 (w-2) locus reveals functional conservation and diversification of ABC transporters for pigmentation in insects. Genes Cells 16: 331-342.
  40. Sakudoh, T., Nakashima, T., Kuroki, Y., Fujiyama, A., Kohara, Y., Honda, N., Fujimoto, H., Shimada, T., Nakagaki, M., Banno, Y., and Tsuchida, K. (2011) Diversity in copy number and structure of a silkworm morphogenetic gene as a result of domestication. Genetics 187: 965-976.
  41. Katsuma, S., Tsuchida, A., Imai-Matsuda, N., Kang, W.-K., and Shimada, T. (2011) Role of the ubiquitin-proteasome system in Bombyx mori nucleopolyhedrovirus infection. J. Gen. Virol. 92: 699-705.
  42. Katsuma, S., Kang, W.-K., Shin-i, T., Ohishi, K., Kadota, K., Kohara, Y., and Shimada, T. (2011) Mass identification of transcriptional units expressed from the Bombyx mori nucleopolyhedrovirus genome. J. Gen. Virol. 92: 200-203.
  43. 藤井 告・嶋田透・阿部広明（2011）油蚕とメンブレントラフィック ．（特集「油蚕と尿酸代謝」）．蚕糸・昆虫バイオテック．80: 93-102.
  44. 嶋田透・藤井 告（2011）昆虫における性決定と性分化の機構 ．（特集「無脊椎動物における性と生殖の制御 -最近の進展」）．比較内分泌学．37: 135-138.
  45. 嶋田透（2011）昆虫のゲノム情報とその利用（第11章）、「脱皮と変態の生物学 - 昆虫と甲殻類のホルモン作用の謎を追う」（園部治之・長澤寛道編）、pp. 331-352、東海大学出版会.
  46. 平山 力・大門高明・嶋田透（2011）カイコ繭フラボノイドの生成機構と生理機能．ファインケミカル 40: 23-28.
  47. Urano, K., Daimon, T., Banno, Y., Mita, K., Terada, T., Shimizu, K., Katsuma, S., and Shimada, T. (2010) Molecular defect of isovaleryl-CoA dehydrogenase in the skunk mutant of silkworm, Bombyx mori. FEBS Journal 277: 4452-4463.
  48. Abe, H., Fujii, T., Shimada, T., and Mita, K. (2010) Novel non-autonomous transposable elements on the W chromosome of the silkworm, Bombyx mori. J. Genet. 89(3) (Special issue - How is sex determined in insects?): 375-387.
  49. Daimon, T.*, Hirayama, S.*, Kanai, M., Ruike, Y., Meng, Y., Kosegawa, E., Nakamura, M., Tsujimoto, G., Katsuma, S., and Shimada, T. (2010) The silkworm Green b locus encodes a quercetin 5-O-glucosyltransferase that produces green cocoons with UV-shielding properties. Proc. Natl. Acad. Sci. USA. 107: 11471-11476. (* These authors contributed equally to this work.)
  50. Niwa, R., Namiki, T.*, Ito, K.*, Shimada-Niwa, Y., Kiuchi, M., Kawaoka, S., Kayukawa, T., Banno, Y., Fujimoto, Y., Shigenobu, S., Kobayashi, S., Shimada, T., Katsuma, S., and Shinoda, T. (2010) Non-molting glossy/shroud encodes a short-chain dehydrogenase/reductase that functions in the "Black Box" of the ecdysteroid biosynthesis pathway. Development 137: 1991-1999. (* These authors contributed equally to this work and should be considered co-first authors.)
  51. Nakanishi, T., Shimada, T., and Katsuma, S. (2010) Characterization of a Bombyx mori nucleopolyhedrovirus mutant lacking both fp25K and p35. Virus Genes 41: 144-148.
  52. Daimon, T., Mitsuhiro, M., Katsuma, S., Abe, H., Mita, K., and Shimada, T. (2010) Recent transposition of yabusame, a novel piggyBac-like transposable element in the silkworm Bombyx mori. Genome 53: 585-593.
  53. Fujii, T., Abe, H., and Shimada, T. (2010) Molecular analysis of sex chromosome-linked mutants in the silkworm Bombyx mori. J. Genet. 89(3) (Special issue - How is sex determined in insects?): 365-374.
  54. Fujii, T., Daimon, T., Uchino, K., Banno, Y., Katsuma, S., Sezutsu, H., Tamura, T., and Shimada, T. (2010) Transgenic analysis of the BmBLOS2 gene that governs the translucency of the larval integument of the silkworm, Bombyx mori. Insect Mol. Biol. 19: 659-667.
  55. Banno, Y., Shimada, T., Kajiura, Z., and Sezutsu, H. (2010) The silkworm - An attractive bioresource supplied by Japan. Exp. Anim. 59: 139-146.
  56. Nakanishi, T., Goto, C., Kobayashi, M., Kang, W.-K., Suzuki, T., Dohmae, N., Matsumoto, S., Shimada, T., and Katsuma, S. (2010) Comparative studies of a lepidopteran baculovirus-specific protein FP25K: Development of a novel BmNPV-based vector with a modified fp25K gene. J. Virol. 84: 5191-5200.
  57. Ito, K., Katsuma, S., Yamamoto, K., Kadono-Okuda, K., Mita, K., and Shimada, T. (2010) Yellow-e determines the color pattern of larval head and tail spots of the silkworm, Bombyx mori. J. Biol. Chem. 285: 5624-5629.
  58. Fujii, T., Ito, K., Katsuma, S., Nakano, R., Shimada, T., and Ishikawa, Y. (2010) Molecular and biochemical characterization of an acetyl-CoA acetyltransferase from the adzuki bean borer Ostrinia scapulalis (Lepidoptera: Crambidae). Insect Biochem. Mol. Biol. 40: 74-48.
  59. Fujii, T., Kuwazaki, S., Yamamoto, K., Abe, H., Ohnuma, A., Katsuma, S., Mita, K., and Shimada, T. (2010) Identification and molecular characterization of a sex chromosome rearrangement causing a soft and pliable (spli) larval body phenotype in the silkworm Bombyx mori. Genome 53: 45-54.
  60. 嶋田 透 (2010) カイコの保存系統とゲノムリソースの組み合わせ―臭蚕遺伝子の同定を例として. ニュースレター"おかいこさま". 18: 1-3.
  61. Katsuma, S. and Shimada, T. (2009) Bombyx mori nucleopolyhedrovirus ORF34 is required for efficient transcription of late and very late genes. Virology 392: 230-237.
  62. Kawaoka, S., Hayashi, N., Suzuki, Y., Abe, H., Sugano, S., Tomari, Y., Shimada, T., and Katsuma, S. (2009) The Bombyx ovary-derived cell line endogenously expresses Piwi/Piwi-interacting RNA complexes. RNA 15: 1258-1264.
  63. Fujii, T., Ozaki, M., Masamoto, T., Katsuma, S., Abe, H., and Shimada, T. (2009) A Bombyx mandarina mutant exhibiting translucent larval skin is controlled by the molybdenum cofactor sulfurase gene. Genes Genet. Syst. 84: 147-152.
  64. Meng, Y., Katsuma, S., Daimon, T., Banno, Y., Uchino, K., Sezutsu, H., Tamura, T., Mita, K., and Shimada, T. (2009) The silkworm mutant lemon (lemon lethal) is a potential insect model for human Sepiapterin reductase deficiency. J. Biol. Chem. 284: 11698 -11705.
  65. Ito, K., Katsuma, S., Yamamoto, K., Kadono-Okuda, K., Mita, K., and Shimada, T. (2009) A 25 bp-long insertional mutation in the BmVarp gene causes the waxy translucent skin of the silkworm, Bombyx mori. Insect Biochem. Mol. Biol. 39: 287-293.
  66. Katsuma, S., Nakanishi, T., and Shimada, T. (2009) Bombyx mori nucleopolyhedrovirus FP25K is essential for maintaining a steady-state level of v-cath expression throughout the infection. Virus Res. 140: 155-160.
  67. Kawaoka, S., Katsuma, S., Meng, Y., Hayashi, N., Mita, K., and Shimada, T. (2009) Identification and characterization of globin genes from two lepidopteran insects, Bombyx mori and Samia cynthia ricini. Gene 431: 33-38.
  68. Meng, Y., Katsuma, S., Mita, K., and Shimada, T. (2009) Abnormal red body coloration of the silkworm, Bombyx mori, is caused by a mutation in a novel kynureninase. Genes Cells 14: 129-140.
  69. Katsuma, S., Nakanishi, T., Daimon, T., and Shimada, T. (2009) N-linked glycans located in the pro-region of Bombyx mori nucleopolyhedrovirus V-CATH are essential for the proper folding of V-CATH and V-CHIA. J. Gen. Virol. 90: 170-176.
  70. 嶋田 透（2009）カイコはなぜクワを食うか―ゲノムからのヒント．特集 シンポジウム「カイコゲノム情報の今後の展開」．蚕糸・昆虫バイオテック 78: 103-107．
  71. 嶋田 透（2009）トランスクリプトーム解析によるカイコのゲノム機能の解明．私の研究ノート．蚕糸・昆虫バイオテック 78: 131-135．
  72. 嶋田 透（2009）桑園から見える教育研究の風景．日本農学アカデミー会報 12: 67-72.
  73. 嶋田 透（2009）カイコの遺伝子ライブラリーとその利用．「虫たちが語る生物学の未来 」（林幸之・大槻吉樹・松本継男・増井博之・藤井博・杉村順夫・矢島正博・古澤寿治編、総227ページ），pp. 64-67，財団法人衣笠会．
  74. 嶋田 透（2009）ゲノムと遺伝子（第２章(2)）．「最新応用昆虫学」（河野義明・田付貞洋編，総264ページ），pp. 24-41，朝倉書店．
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  76. Futahashi, R.*, Sato, J.*, Meng, Y.*, Okamoto, S., Daimon, T., Yamamoto, K., Suetsugu, Y., Narukawa, J., Takahashi, H., Banno, Y., Katsuma, S., Shimada, T., Mita, K., and Fujiwara, H. (2008) yellow and ebony are the responsible genes for the larval color mutants of the silkworm Bombyx mori. Genetics 180: 1995-2005. (* These authors contributed equally to this work)
  77. Katsuma, S., Fujii, T., Kawaoka, S., and Shimada, T. (2008) Bombyx mori nucleopolyhedrovirus SNF2 global transactivator homologue (Bm33) enhances viral pathogenicity in B. mori larvae. J. Gen. Virol. 89: 3039-3046.
  78. Arunkumar, K. P., Tomar, A., Daimon, T., Shimada, T., and Nagaraju, J. (2008) WildSilkbase: An EST database of wild silkmoths. BMC Genomics 9: 338.
  79. Katsuma, S., Horie, S., and Shimada, T. (2008) The fibroblast growth factor homolog of Bombyx mori nucleopolyhedrovirus enhances systemic virus propagation in B. mori larvae. Virus Res. 137: 80-85.
  80. Ito, K., Kidokoro, K., Sezutsu, H., Nohata, N., Yamamoto, K., Kobayashi, I., Uchino, K., Kalyebi, A., Eguchi, R., Hara, W., Tamura, T., Katsuma, S., Shimada, T., Mita, K., and Kadono-Okuda, K. (2008) Deletion of a gene encoding an amino acid transporter in the midgut membrane causes resistance to a Bombyx parvo-like virus. Proc. Natl. Acad. Sci. USA. 105: 7523-7527.
  81. Katsuma, S., Kawaoka, S., Mita, K., and Shimada, T. (2008) Genome-wide survey for baculoviral host homologs using the Bombyx genome sequence. Insect Biochem. Mol. Biol. 38: 1080-1086.
  82. Daimon, T., Taguchi, T., Meng, Y., Katsuma, S., Mita, K., and Shimada, T. (2008) Beta-fructofuranosidase genes of the silkworm, Bombyx mori: Insight into enzymatic adaptation of B. mori to toxic alkaloids in mulberry latex. J. Biol. Chem. 283: 15271-15279.
  83. Kawaoka. S., Hayashi, N., Katsuma, S., Kishino, H., Kohara, Y., Mita, K., and Shimada, T. (2008) Bombyx small RNAs: Genomic defense system against transposons in the silkworm, Bombyx mori. Insect Biochem. Mol. Biol. 38: 1058-1065.
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  85. Tabunoki, H., Shimada, T., Banno, Y., Sato, R., Kajiwara, H., Mita, K., and Satoh, J. (2008) Identification of Bombyx mori 14-3-3 orthologs and the interactor Hsp60. Neurosci. Res. 61: 271-280.
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  87. Abe, H., Fujii, T., Tanaka, N., Yokoyama, T., Kakehashi, K., Ajimura, N., Mita, M., Banno, Y., Yasukochi, Y., Oshiki, T., Nenoi, M., Ishikawa, T., and Shimada, T. (2008) Identification of the female-determining region of the W chromosome in Bombyx mori. Genetica 133: 269-282.
  88. Kawaoka, S., Katsuma, S., Daimon, T., Isono, R., Omuro, S., Mita, K., and Shimada, T. (2008) Functional analysis of four Gloverin-like genes in the silkworm, Bombyx mori. Arch. Insect Biochem. Physiol. 67: 87-96.
  89. Meng, Y., Omuro, N., Funaguma, S., Daimon, T., Kawaoka, S., Katsuma, S., and Shimada, T. (2008) Prominent down-regulation of storage protein genes after bacterial challenge in eri-silkworm, Samia cynthia ricini. Arch. Insect Biochem. Physiol. 67: 9-19.
  90. Suzuki, M. G., Imanishi, S., Dohmae, N., Nishimura, T., Shimada, T., and Matsumoto, S. (2008) Establishment of a novel in vivo sex-specific splicing assay system to identify a trans-acting factor that negatively regulates splicing of Bmdsx female exons . Mol. Cell. Biol. 28: 333-343.
  91. 河岡慎平・嶋田透・勝間進（2008）カイコの生殖巣に存在するsmall RNAの特性と機能． 蚕糸・昆虫バイオテック 77(3): 219-225.
  92. Orihara, Y., Hamamoto, H., Kasuga, H., Shimada, T., Kawaguchi, Y., and Sekimizu, K. (2007) Evaluation of therapeutic effects of antiviral agents using a silkworm baculovirus infection model. J. Gen. Virol. 89: 188-194.
  93. Katsuma, S., Mita, K., and Shimada, T. (2007) ERK- and JNK-dependent signaling pathways contribute to Bombyx mori nucleopolyhedrovirus infection. J. Virol. 81: 13700-13709.
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  95. Daimon, T., Katsuma, S., Kang, W.-K., and Shimada, T. (2007) Functional characterization of chitinase from Cydia pomonella granulovirus. Arch. Virol. 152: 1655-1664.
  96. Fujii, T. and Shimada, T. (2007) Sex determination in the silkworm, Bombyx mori: a female determinant on the W chromosome and the sex-determining gene cascade. Semin. Cell Dev. Biol. 18: 379-388.
  97. Quan, G.-X., Kobayashi, I., Kojima, K., Uchino, K., Kanda, T., Sezutsu, H., Shimada, T., and Tamura, T. (2007) Rescue of white egg 1 mutant by introduction of the wild-type Bombyx kynurenine 3-monooxygenase gene. Insect Sci. 14: 85-92.
  98. Iwanaga, M., Shimada, T., Kobayashi, M., and Kang, W.-K. (2007) Identification of differentially expressed host genes in Bombyx mori nucleopolyhedrovirus infected cells by using subtractive hybridization. Appl. Entomol. Zool. 42: 151-159.
  99. Funaguma, S., Hashimoto, S., Suzuki, Y., Omuro, N., Sugano, S., Mita, K., Katsuma, S., and Shimada, T. (2007) SAGE analysis of early oogenesis in the silkworm, Bombyx mori. Insect Biochem. Mol. Biol. 37:147-154.
  100. Daimon, T., Katsuma S., and Shimada, T. (2007) Mutational analysis of active site residues of chitinase from Bombyx mori nucleopolyhedrovirus. Virus Res. 124: 168-175.
  101. Fujii, T., Yokoyama, T., Ninagi, O., Kakehashi, K., Obara, Y., Nenoi, M., Ishikawa, T., Mita, K., Shimada, T., and Abe, H. (2007) Isolation and characterization of sex chromosome rearrangements generating male muscle dystrophy and female abnormal oogenesis in the silkworm, Bombyx mori. Genetica 130: 267-280.
  102. 嶋田透（2007）ゲノムと遺伝子（第１章），「昆虫生理生態学」（河野義明・田付貞洋編，288ページ），pp.1-14，朝倉書店
  103. Katsuma, S., Daimon, T., Horie, S., Kobayashi, M., and Shimada, T. (2006) N-linked glycans of Bombyx mori nucleopolyhedrovirus fibroblast growth factor are crucial for its secretion. Biochem. Biophys. Res. Commun. 350: 1069-1075.
  104. Katsuma, S., Horie, S., Daimon, T., Iwanaga, M., and Shimada, T. (2006) In vivo and in vitro analyses of a Bombyx mori nucleopolyhedrovirus mutant lacking functional vfgf. Virology 355: 62-70.
  105. Daimon, T., Katsuma, S., Kang, W.-K., and Shimada, T. (2006) Comparative studies of Bombyx mori nucleopolyhedrovirus chitinase and its host ortholog, BmChi-h. Biochem. Biophys. Res. Commun. 345: 825-833.
  106. Katsuma, S., Daimon, T., Mita, K., and Shimada, T. (2006) Lepidopteran ortholog of Drosophila Breathless is a receptor for the baculoviral fibroblast growth factor. J. Virol. 80: 5474-5481.
  107. Fujii, T., Tanaka, N., Yokoyama, T., Ninaki, O., Oshiki, T., Ohnuma, A., Tazima, Y., Banno, Y., Ajimura, M., Mita, K., Seki, M., Ohbayashi, F., Shimada, T., and Abe, H. (2006) The female-killing chromosome of the silkworm, Bombyx mori, was generated by translocation between the Z and W chromosomes. Genetica 127: 253-265.
  108. Tsukioka, H., Takahashi, M., Mon, H., Okano, K., Mita, K., Shimada, T., Lee, J. M,, Kawaguchi, Y., Koga, K., and Kusakabe, T. (2006) Role of the silkworm argonaute2 homolog gene in double-strand break repair of extrachromosomal DNA. Nucleic Acids Res. 34: 1092-1101.
  109. Zhong, Y.-S., Mita, K., Shimada, T., and Kawasaki, H. (2006) Glycine rich protein genes, encoding proteins constructing insect cuticle, have different developmental profiles from other cuticle protein genes in Bombyx mori. Insect Biochem. Mol. Biol. 36: 99-110.
  110. 嶋田 透 (2006) 昆虫の比較ゲノム：カイコゲノムから見た多様性と特異性，ゲノムから読み解く生命システム―比較ゲノムからのアプローチ 第9回．細胞工学 25: 426-431.
  111. 木口 憲爾・小林 正彦・茅野 春雄・井上 元・嶋田 透 ・藤井 博・伴野 豊・竹田 敏・小瀬川 英一・清水 治・鈴木 幸一・小林 淳・蜷木 理（2006）カイコの教育・研究利用の現状 : アンケート調査結果より．蚕糸・昆虫バイオテック．75: 123-127.

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