AE-Bio 東京大学農学生命科学研究科 生産環境生物学専攻 close

勝間 進


勝間 進


生産・環境生物学専攻
昆虫遺伝研究室


准教授

 略 歴
1995年 東京大学卒業
1997年 東京大学大学院修士課程修了
2003年 博士(農学)取得(東京大学)

 研究概要
 バキュロウイルスは、高分子DNA(約130kbp)をゲノムとして持つ高度に進化したウイルスである。アポトーシス研究の一大発見とされる IAP (inhibitor of apoptosis) family やP35はバキュロウイルスから発見されたものであり、バキュロウイルスには生物学的に重要な遺伝子が保存されていると考えられる。しかしながら、機能が明らかにされている遺伝子は 1/3 程度であり、今後の研究によって重要な機能を持つ遺伝子がさらに発見できる可能性がある。また、これらバキュロウイルス遺伝子のほ乳類における機能的ホモログをクローニング、機能解析することによって生物学的に普遍である新たな知見が得られると考えられる。
 前述の通りバキュロウイルスは大きなゲノムを持つことから、自身の複製に関係した遺伝子以外に宿主を巧みに制御するような遺伝子を多く保持している。例えば、キチナーゼやシステインプロテアーゼ等の感染後の個体の崩壊に関与する遺伝子、昆虫ホルモンであるエクダイソンを不活化する遺伝子などである。最近筆者らが報告したvfgf は哺乳類の成長因子の一つである FGF (Fibroblast Growth Factor) と高いホモロジーを持つバキュロウイルス間で高度に保存されている遺伝子の一つである。その機能は明らかにされていないが、FGF を持つウイルスは現在までバキュロウイルスしか報告されていないことから、このような遺伝子の機能解析は進化生物学的に意味があることであると考えられる。

 最近の研究成果
  1. Iwanaga M, Shibano Y, Ohsawa T, Fujita T, Katsuma S, and Kawasaki H., Involvement of HSC70-4 and other inducible HSPs in Bombyx mori nucleopolyhedrovirus infection. Virus Research, in press.
  2. Fujii T, Suzuki MG, Katsuma S, Ito K, Rong Y, Matsumoto S, Ando T, and Ishikawa Y., Discovery of a disused desaturase gene from the pheromone gland of the moth Ascotis selenaria, which secretes an epoxyalkenyl sex pheromone. Biochemical and Biophysical Research Communications, in press.
  3. Uemura N, Tabunoki H, Suzuki T, Ishikawa K, Nojima Y, Katsuma S, Sato R, and Satoh JI., Production of wild-type and mutant-type human DAP12 proteins by Bombyx mori nucleopolyhedrovirus vector. Bioscience, Biotechnology, and Biochemistry, in press.
  4. Suetsugu Y, Futahashi R, Kanamori H, Kadono-Okuda K, Sasanuma SI, Narukawa J, Ajimura M, Jouraku A, Namiki N, Shimomura M, Sezutsu H, Osanai-Futahashi M, Suzuki MG, Daimon T, Shinoda T, Taniai K, Asaoka K, Niwa R, Kawaoka S, Katsuma S, Tamura T, Noda H, Kasahara M, Sugano S, Suzuki Y, Fujiwara H, Kataoka H, Arunkumar KP, Tomar A, Nagaraju J, Goldsmith MR, Feng Q, Xia Q, Yamamoto K, Shimada T, and Mita K., Large scale full-length cDNA sequencing reveals a unique genomic landscape in a lepidopteran model insect, Bombyx mori. G3 (Bethesda), 2013, 3, 1481-1492.
  5. Shoji K, Kiuchi T, Hara K, Kawamoto M, Kawaoka S, Arimura S, Tsutsumi N, Sugano S, Suzuki Y, Shimada T, and Katsuma S., Characterization of a novel chromodomain-containing gene from the silkworm, Bombyx mori. Gene, 2013, 527, 649-654.
  6. Izumi N, Kawaoka S, Yasuhara S, Suzuki Y, Sugano S, Katsuma S, and Tomari Y., Hsp90 facilitates accurate loading of precursor piRNAs into PIWI proteins. RNA, 2013, 19, 896-901.
  7. Bono F, De Smet F, Herbert C, De Bock K, Georgiadou M, Fons P, Tjwa M, Alcouffe C, Ny A, Bianciotto M, Jonckx B, Murakami M, Lanahan A, Michielsen C, Sibrac D, Dol-Gleizes F, Mazzone M, Zacchigna S, Herault JP, Fischer C, Rigon P, Ruiz de Almodovar C, Claes F, Blanc I, Poesen K, Zhang J, Segura I, Gueguen G, Bordes MF, Lambrechts D, Broussy R, van de Wouwer M, Michaux C, Shimada T, Jean I, Blacher S, Noel A, Motte P, Rom E, Rakic JM, Katsuma S, Schaeffer P, Yayon A, Schepdael VA, Schwalbe H, Gervasio F, Carmeliet G, Rozensky J, Dewerchin M, Simons M, Christopoulos A, Herbert JM, and Carmeliet P., Inhibition of tumor angiogenesis and growth by a small-molecule multi-FGF receptor blocker with allosteric properties. Cancer Cell, 2013, 23, 477-488.
  8. Wang L, Kiuchi T, Fujii T, Daimon T, Li M, Banno Y, Kikuta S, Kikawada T, Katsuma S, and Shimada T., Mutation of a novel ABC transporter gene is responsible for the failure to incorporate uric acid in the epidermis of ok mutants of the silkworm, Bombyx mori. Insect Biochemistry and Molecular Biology, 2013, 43, 562-571.
  9. Lin Y, Meng Y, Wang Y-X, Luo J, Katsuma S, Yang C-W, Banno Y, Kusakabe T, Shimada T, and Xia Q-Y., Vitellogenin receptor mutation leads to the oogenesis mutant phenotype 'scanty vitellin' of the silkworm, Bombyx mori. Journal of Biological Chemistry, 2013, 288, 13345-13355.
  10. Fujii T, Abe H, Kawamoto M, Katsuma S, Banno Y, and Shimada T., Albino (al) is a tetrahydrobiopterin (BH4)-deficient mutant of the silkworm Bombyx mori. Insect Biochemistry and Molecular Biology, 2013, 43, 594-600.
  11. Ishihara G, Shimada T, and Katsuma S., Functional characterization of Bombyx mori nucleopolyhedrovirus CG30 protein. Virus Research, 2013, 174, 52-59.
  12. Tsuchida A, Ishihara G, Shimada T, and Katsuma S., Dimerization and proper degradation of Bombyx mori nucleopolyhedorivirus IE2 are required for efficient virus growth in B. mori larvae. Applied Entomology and Zoology, 2013, 48, 125-130.
  13. Ito K, Kidokoro K, Shimura S, Katsuma S, and Kadono-Okuda K., Detailed investigation of the sequential pathological changes in silkworm larvae infected with Bombyx densovirus type 1, Journal of Invertebrate Pathology, 2013, 112: 213-218.
  14. Wang L, Kiuchi T, Fujii T, Daimon T, Li M, Banno Y, Katsuma S, and Shimada T., Reduced expression of the dysbindin-like gene in the Bombyx mori ov mutant exhibiting mottled translucency of the larval skin. Genome, 2013, 56, 101-108.
  15. Kawaoka S*, Hara K*, Shoji K, Kobayashi M, Shimada T, Sugano S, Tomari Y, Suzuki Y, and Katsuma S., The comprehensive epigenome map of piRNA clusters. Nucleic Acids Research, 2013, 41, 1581-1590. (* These authors contributed equally to this work.)
  16. Hori T, Kiuchi T, Shimada T, Nagata M, and Katsuma S., Silkworm plasmatocytes are more resistant than other hemocyte morphotypes to Bombyx mori nucleopolyhedrovirus infection. Journal of Invertebrate Pathology, 2013, 112, 102-104.
  17. Katsuma S and Shimada T., Comparative studies of Bombyx mori nucleopolyhedrovirus infection in BmN4 cell lines maintained in different laboratories. Journal of Insect Biotechnology and Sericology, 2012, 81, 7-12
  18. Fujii T, Y.Banno Y, Abe H, Katsuma S, and Shimada T., A homolog of the human Hermansky-Pudluck Syndrome-5 (HPS5) gene is responsible for the oa larval translucent mutants in the silkworm, Bombyx mori. Genetica, 2012, 140, 463-468.
  19. Daimon T, Fujii T, Fujii T, Yokoyama T, Katsuma S, Shinoda T, Shimada T, and Ishikawa Y., Reinvestigation of the sex pheromone of the wild silkmoth, Bombyx mandarina: The effects of bombykal and bombykyl acetate. Journal of Chemical Ecology, 2012, 38, 1031-1035.
  20. Ito K, Kidokoro K, Katsuma S, Shimada T, Yamamoto K, Mita K, and Kadono-Okuda K., Positional cloning of a gene responsible for the cts mutation of the silkworm, Bombyx mori. Genome, 2012, 55, 493-504.
  21. Katsuma S, Koyano Y, Kang W-K, Kokusho R, Kamita SG, and Shimada T., The baculovirus uses a captured host phosphatase to induce enhanced locomotory activity in host caterpillars. PLoS Pathogens, 2012, 8, e1002644.
  22. Daimon T, Kozaki T, Niwa R, Kobayashi I, Furuta K, Namiki T, Uchino K, Banno Y, Katsuma S, Tamura T, Mita K, Sezutsu H, Nakayama M, Itoyama K, Shimada T, and Shinoda T., Precocious metamorphosis in the juvenile hormone-deficient mutant of the silkworm, Bombyx mori. PLoS Genetics, 2012, 8, e1002486.
  23. Hara K, Fujii T, Suzuki Y, Sugano S, Shimada T, Katsuma S, and Kawaoka S., Altered expression of testis-specific genes, piRNAs, and transposons in the silkworm ovary masculinized by a W chromosome mutation. BMC Genomics, 2012, 13, 119.
  24. Kang W-K, Katsuma S, Matsuda-Imai N, Kurihara M, Yoshiga T, Shimada T, and Matsumoto S., Identification and characterization of host factors interacting with Bombyx mori nucleopolyhedrovirus ORF8. Journal of Microbiology, 2012, 50, 469-477.
  25. Daimon T*, Fujii T*, Yago M, Hsu Y-F, Nakajima Y, Fujii T, Katsuma S, Ishikawa Y, and Shimada T., Female sex pheromone and male behavioral responses of the bombycid moth Trilocha varians: comparison with those of the domesticated silkmoth Bombyx mori. Naturwissenschaften, 2012, 99, 207-215. (* These authors contributed equally to this work.)
  26. Katsuma S, Kobayashi J, Koyano Y, Matsuda-Imai N, Kang W-K, and Shimada T., Baculovirus-encoded protein BV/ODV-E26 determines tissue tropism and virulence in lepidopteran insects. Journal of Virology, 2012, 86, 2545-2555.
  27. Iwanaga M, Hitotsuyama T, Katsuma S, Ishihara G, Daimon T, Shimada T, Imanishi S, and Kawasaki H., Infection study of Bombyx mori macula-like virus (BmMLV) using a BmMLV-negative cell line and an infectious cDNA clone. Journal of Virological Methods, 2012, 179, 316-324.
  28. Kawaoka S*, Mitsutake H*, Kiuchi T, Kobayashi M, Yoshikawa M, Suzuki Y, Sugano S, Shimada T, Kobayashi J, Tomari Y, and Katsuma S., A role for transcription from a piRNA cluster in de novo piRNA production. RNA, 2012, 18, 256-273. (* These authors contributed equally to this work)
  29. Daimon T, Yago M, Hsu Y-F, Fujii T, Nakajima Y, Kokusho R, Abe H, Katsuma S, and Shimada T., Molecular phylogeny, laboratory rearing, and karyotype of the bombycid moth, Trilocha varians. Journal of Insect Science, 2012, 12, 49.
  30. Fujii T, Abe H, Yamamoto K, Katsuma S, and Shimada T., Interspecies linkage analysis of mo, a Bombyx mori locus associated with mosaicism and gynandromorphism. Genetica, 2011, 139, 1323-1329.
  31. Fujii T, Fujii T, Namiki S, Abe H, Sakurai T, Ohnuma A, Kanzaki R, Katsuma S, Ishikawa Y, and Shimada T., Sex-linked transcription factor involved in a shift of sex pheromone preference in the silkmoth, Bombyx mori. Proceedings of the National Academy of Sciences of the United States of America, 2011, 108, 18038-18043.
  32. Kawaoka S, Kadota K, Arai Y, Suzuki Y, Fujii T, Abe H, Yasukochi Y, Mita K, Sugano S, Shimizu K, Tomari Y, Shimada T and Katsuma S., The silkworm W chromosome is a source of female-enriched piRNAs. RNA, 2011, 17, 2144-2151.
  33. Kawaoka S, Izumi N, Katsuma S, and Tomari Y., 3' end formation of PIWI-interacting RNAs in vitro. Molecular Cell, 2011, 43, 1015-1022.
  34. Kokusho R, Zhang C-X, Shimada T, and Katsuma S., Comparative analysis of budded virus infectivity of Bombyx mandarina and B. mori nucleopolyhedroviruses. Virus Genes, 2011, 43, 313-317.
  35. Kawaoka S, Arai Y, Kadota K, Suzuki Y, Hara K, Sugano S, Shimizu K, Tomari Y, Shimada T. and Katsuma S., Zygotic amplification of secondary piRNAs during the silkworm embryogenesis. RNA, 2011, 17, 1401-1407.
  36. Kiuchi T, Banno Y, Katsuma S, and Katsuma S., Mutations in an amino acid transporter gene are responsible for sex-linked translucent larval skin of the silkworm, Bombyx mori. Insect Biochemistry and Molecular Biology, 2011, 41, 680-687.
  37. Fujii T, Ito K, Tatematsu M, Shimada T, Katsuma S, and Ishikawa Y., Sex pheromone desaturase functioning in a primitive Ostrinia moth is cryptically conserved in congeners' genomes. Proceedings of the National Academy of Sciences of the United States of America, 2011, 108, 7102-7106.
  38. Tabunoki H, Ode H, Banno Y, Katsuma S, Shimada T, Mita K, Yamamoto K, Sato R, Ishii-Nozawa R, and Satoh J-I., BmDJ-1 is a key regulator for the developmental oxidative modification of the silkworm, Bombyx mori. PLoS One, 2011, 6, e17683.
  39. Fujii T, Abe H, Katsuma S, and Shimada T., Identification and characterization of the fusion transcript, composed of the apterous homolog and a putative protein phosphatase gene, generated by 1.5-Mb interstitial deletion in the vestigial (Vg) mutant of Bombyx mori. Insect Biochemistry and Molecular Biology, 2011, 41, 306-312.
  40. Katsuma S, Tsuchida A, Imai-Matsuda N, Kang W-K, and Shimada T., Role of the ubiquitin-proteasome system in Bombyx mori nucleopolyhedrovirus infection. Journal of General Virology, 2011, 92, 699-705.
  41. Katsuma S, Kang W-K, Shin-i T, Ohishi K, Kadota K, Kohara Y, and Shimada T., Mass identification of transcriptional units expressed from the Bombyx mori nucleopolyhedrovirus genome. Journal of General Virology, 2011, 92, 200-203.
  42. Urano K, Daimon T, Banno Y, Mita K, Terada T, Shimizu K, Katsuma S, and Shimada T., Molecular defect of isovaleryl-CoA dehydrogenase in the skunk mutant of silkworm, Bombyx mori. FEBS Journal , 2010, 277, 4452-4463.
  43. Iwasaki S, Kobayashi M, Yoda M, Sakaguchi Y, Katsuma S, Suzuki T, and Tomari Y., Hsc70/Hsp90 chaperone machinery mediates ATP-dependent RISC loading of small RNA duplexes. Molecular Cell, 2010, 39, 292-299.
  44. Daimon T*, Hirayama S*, Kanai M, Ruike Y, Meng Y, Kosegawa E, Nakamura M, Tsujimoto G, Katsuma S, and Shimada T., The silkworm Green b locus encodes a quercetin 5-O-glucosyltransferase that produces green cocoons with UV-shielding properties. Proceedings of the National Academy of Sciences of the United States of America, 2010, 107, 11471-11476. (* These authors contributed equally to this work.)
  45. Niwa R*, Namiki T*, Ito K*, Shimada-Niwa Y, Kiuchi M, Kawaoka S, Kayukawa T, Banno Y, Fujimoto Y, Shigenobu S, Kobayashi S, Shimada T, Katsuma S, and Shinoda T., Non-molting glossy/shroud encodes a short-chain dehydrogenase/reductase that functions in the "Black Box" of the ecdysteroid biosynthesis pathway. Development, 2010, 137, 1991-1999. (* These authors contributed equally to this work.)
  46. Nakanishi T, Shimada T, and Katsuma S., Characterization of a Bombyx mori nucleopolyhedrovirus mutant lacking both fp25K and p35. Virus Genes, 2010, 41, 144-148.
  47. Daimon T, Mitsuhiro M, Katsuma S, Abe H, Mita K, and Shimada T., Recent transposition of yabusame, a novel piggyBac-like transposable element in the silkworm Bombyx mori. Genome, 2010, 53, 585-593.
  48. Fujii T, Daimon T, Uchino K, Banno Y, Katsuma S, Sezutsu H, Tamura T, and Shimada T., Transgenic analysis of the BmBLOS2 gene that governs the translucency of the larval integument of the silkworm, Bombyx mori. Insect Molecular Biology, 2010, 19, 659-667.
  49. Nakanishi T, Goto C, Kobayashi M, Kang WK, Suzuki T, Dohmae N, Matsumoto S, Shimada T, and Katsuma S., Comparative studies of a lepidopteran baculovirus-specific protein FP25K: Development of a novel BmNPV-based vector with a modified fp25K gene. Journal of Virology, 2010, 84, 5191-5200.
  50. Ito K, Katsuma S, Yamamoto K, Kadono-Okuda K, Mita K, and Shimada T., Yellow-e determines the color pattern of larval head and tail spots of the silkworm, Bombyx mori. Journal of Biological Chemistry, 2010, 285, 5624-5629.
  51. Fujii T, Ito K, Katsuma S, Nakano R, Shimada T, and Ishikawa Y., Molecular and biochemical characterization of an acetyl-CoA acetyltransferase from the adzuki bean borer Ostrinia scapulalis (Lepidoptera: Crambidae). Insect Biochemistry and Molecular Biology, 2010, 40, 74-48.
  52. Fujii T, Kuwazaki S, Yamamoto K, Abe H, Ohnuma A, Katsuma S, Mita K, and Shimada T., Identification and molecular characterization of a sex chromosome rearrangement causing a soft and pliable (spli) larval body phenotype in the silkworm Bombyx mori. Genome, 2010, 53, 45-54.
  53. Katsuma S and Shimada T., Bombyx mori nucleopolyhedrovirus ORF34 is required for efficient transcription of late and very late genes. Virology, 2009, 392, 230-237.
  54. Kawaoka S, Hayashi N, Suzuki Y, Abe H, Sugano S, Tomari Y, Shimada T, and Katsuma S., The Bombyx ovary-derived cell line endogenously expresses Piwi/Piwi-interacting RNA complexes. RNA, 2009, 15, 1258-1264.
  55. Fujii T, Ozaki M, Masamoto T, Katsuma S, Abe H, and Shimada T., A Bombyx mandarina mutant exhibiting translucent larval skin is controlled by the molybdenum cofactor sulfurase gene. Genes and Genetic Systems, 2009, 84, 147-152.
  56. Meng Y, Katsuma S, Daimon T, Banno Y, Uchino K, Sezutsu H, Tamura T, Mita K, and Shimada T., The silkworm mutant lemon (lemon lethal) is a potential insect model for human Sepiapterin reductase deficiency. Journal of Biological Chemistry, 2009, 284, 11698 -11705.
  57. Ito K, Katsuma S, Yamamoto K, Kadono-Okuda K, Mita K, and Shimada T., A 25 bp-long insertional mutation in the BmVarp gene causes the waxy translucent skin of the silkworm, Bombyx mori. Insect Biochemistry and Molecular Biology, 2009, 39, 287-293.
  58. Katsuma S, Nakanishi T, and Shimada T., Bombyx mori nucleopolyhedrovirus FP25K is essential for maintaining a steady-state level of v-cath expression throughout the infection. Virus Research, 2009, 140, 155-160.
  59. Sato Y, Morita R, Katsuma S, Nishimura M, Tanaka A, Kusaba M., Two short-chain dehydrogenase/reductases, NON-YELLOW COLORING 1 and NYC1-LIKE, are required for chlorophyll b and light-harvesting complex II degradation during senescence in rice. Plant Journal, 2009, 57, 120-131.
  60. Kawaoka S, Katsuma S, Meng Y, Hayashi N, Mita K, and Shimada S., Identification and characterization of globin genes from two lepidopteran insects, Bombyx mori and Samia cynthia ricini. Gene, 2009, 431, 33-38.
  61. Meng Y, Katsuma S, Mita K, and Shimada T., Abnormal red body coloration of the silkworm, Bombyx mori, is caused by a mutation in a novel kynureninase. Genes to Cells, 2009, 14, 129-140.
  62. Katsuma S, Nakanishi T, Daimon T, and Shimada T., N-linked glycans located in the pro-region of Bombyx mori nucleopolyhedrovirus V-CATH are essential for the proper folding of V-CATH and V-CHIA. Journal of General Virology, 2009, 90, 170-176.
  63. The International Silkworm Genome Consortium*, The genome of a lepidopteran model insect, the silkworm Bombyx mori. Insect Biochemistry and Molecular Biology, 2008, 38, 1036-1045. (* Chinese group: Xia Q, Wang J, Zhou Z, Li R, Fan W, Cheng D, Cheng T, Qin J, Duan J, Xu H, Li Q, Li N, Wang M, Dai F, Liu C, Lin Y, Zhaoa P, Zhang H, Liu S, Zha X, Li C, Zhao A, Pan M, Pan G, Shen Y, Gao Z, Wang Z, Wang G, Wu Z, Hou Y, Chai C, Yu Q, He N, Zhang Z, Li S, Yang H, Lu C, Wang J, and Xiang Z, Japanese group : Mita K, Kasahara M, Nakatani Y, Yamamoto K, Abe H, Ahsan B, Daimon T, Doi K, Fujii T, Fujiwara H, Fujiyama A, Futahashi R, Hashimoto S, Ishibashi J, Iwami M, Kadono-Okuda K, Kanamori H, Kataoka H, Katsuma S, Kawaoka S, Kawasaki H, Kohara Y, Kozaki T, Kuroshu R. M, Kuwazaki S, Matsushima K, Minami H, Nagayasu Y, Nakagawa T, Narukawa J, Nohata J, Ohishi K, Ono Y, Osanai-Futahashi M, Ozaki K, Qu W, Roller L, Sasaki S, Sasaki T, Seino A, Shimomura M, Shimomura M, Shin-I T, Shinoda T, Shiotsuki T, Suetsugu Y, Sugano S, Suwa M, Suzuki Y, Takiya S, Tamura T, Tanaka H, Tanaka Y, Touhara K, Yamada T, Yamakawa M, Yamanaka N, Yoshikawa H, Zhong Y, Shimada T, and Morishita S.)
  64. Katsuma S, Kawaoka S, Mita K, and Shimada T., Genome-wide survey for baculoviral host homologs using the Bombyx genome sequence. Insect Biochemistry and Molecular Biology, 2008, 38, 1080-1086.
  65. Kawaoka S, Hayashi N, Katsuma S, Kishino H, Kohara Y, Mita K, and Shimada T., Bombyx small RNAs: Genomic defense system against transposons in the silkworm, Bombyx mori. Insect Biochemistry and Molecular Biology, 2008, 38, 1058-1065.
  66. Fujii T, Abe H, Katsuma S, Mita K, and Shimada T., Mapping of sex-linked genes onto the genome sequence using various aberrations of the Z chromosome in Bombyx mori. Insect Biochemistry and Molecular Biology, 2008, 38, 1072-1079.
  67. Futahashi R*, Sato J*, Meng Y*, Okamoto S, Daimon T, Yamamoto K, Suetsugu Y, Narukawa J, Takahashi H, Banno Y, Katsuma S, Shimada, T., Mita, K., and Fujiwara, H., yellow and ebony are the responsible genes for the larval color mutants of the silkworm Bombyx mori. Genetics, 2008, 180, 1995-2005. (* These authors contributed equally to this work)
  68. Katsuma S., Fujii T, Kawaoka S, and Shimada T., Bombyx mori nucleopolyhedrovirus SNF2 global transactivator homologue (Bm33) enhances viral pathogenicity in B. mori larvae. Journal of General Virology, 2008, 89, 3039-3046.
  69. Katsuma S, Horie S, and Shimada T., The fibroblast growth factor homolog of Bombyx mori nucleopolyhedrovirus enhances systemic virus propagation in B. mori larvae. Virus Research, 2008, 137, 80-85.
  70. Ito K, Kidokoro K, Sezutsu H, Nohata N, Yamamoto K, Kobayashi I, Uchino K, Kalyebi A, Eguchi R, Hara W, Tamura T, Katsuma S, Shimada T, Mita K, and Kadono-Okuda K., Deletion of a gene encoding an amino acid transporter in the midgut membrane causes resistance to a Bombyx parvo-like virus. Proceedings of the National Academy of Sciences of the United States of America, 2008, 105, 7523-7527.
  71. Katsuma S, Kawaoka S, Mita K, and Shimada T., Genome-wide survey for baculoviral host homologs using the Bombyx genome sequence. Insect Biochemistry and Molecular Biology, accepted.
  72. Daimon T, Taguchi T, Meng Y, Katsuma S, Mita K, and Shimada T., Beta-fructofuranosidase genes of the silkworm, Bombyx mori: Insight into enzymatic adaptation of B. mori to toxic alkaloids in mulberry latex. Journal of Biological Chemistry , 2008, 283, 15271-15279.
  73. Kawaoka S, Hayashi N, Katsuma S, Kishino H, Kohara Y, Mita K, and Shimada T., Bombyx small RNAs: Genomic defense system against transposons in the silkworm, Bombyx mori. Insect Biochemistry and Molecular Biology, accepted.
  74. Fujii T, Abe H, Katsuma S, Mita K, and Shimada T., Mapping of sex-linked genes onto the genome sequence using various aberrations of the Z chromosome in Bombyx mori. Insect Biochemistry and Molecular Biology, accepted.
  75. Kawaoka S, Minami K, Katsuma S, Mita K, and Shimada T., Developmentally synchronized expression of two Bombyx mori Piwi subfamily genes, SIWI and BmAGO3 in germ-line cells. Biochemical and Biophysical Research Communications, 2008, 367,755-760.
  76. Tanaka T, Katsuma S, Adachi T, Koshimizu TA, Hirasawa A, Tsujimoto G., Free fatty acids induce cholecystokinin secretion through GPR120. Naunyn-Schmiedeberg's Archives of Pharmacology, in press.
  77. Meng Y, Omuro N, Funaguma S, Daimon T, Kawaoka S, Katsuma S, and Shimada T., Prominent down-regulation of storage protein genes after bacterial challenge in eri-silkworm, Samia cynthia ricini. Archives of Insect Biochemistry and Physiology, 2008, 67, 9-19.
  78. Kawaoka S, Katsuma S, Daimon T, Isono R, Omuro S, Mita K, and Shimada T., Functional analysis of four Gloverin-like genes in the silkworm, Bombyx mori. Archives of Insect Biochemistry and Physiology, 2008, 67, 87-96.
  79. Katsuma S, Mita K, and Shimada T., ERK- and JNK-dependent signaling pathways contribute to Bombyx mori nucleopolyhedrovirus infection. Journal of Virology, 2007, 81, 13700-13709.
  80. Daimon T, Katsuma S, Kang WK, and Shimada T., Functional characterization of chitinase from Cydia pomonella granulovirus. Archives of Virology, 2007, 152, 1655-1664.
  81. Ruike Y, Katsuma S, Hirasawa A, Tsujimoto G., Glucocorticoid-induced alternative promoter usage for a novel 5' variant of granzyme A. Journal of Human Genetics, 2007, 52, 172-178.
  82. Funaguma S, Hashimoto S, Suzuki Y, Omuro N, Sugano,S, Mita K, Katsuma S, and Shimada T., SAGE analysis of early oogenesis in the silkworm, Bombyx mori. Insect Biochemistry and Molecular Biology, 2007, 37, 147-154.
  83. Daimon T, Katsuma S, and Shimada T., Mutational analysis of active site residues of chitinase from Bombyx mori nucleopolyhedrovirus. Virus Research, 2007, 124, 168-175.
  84. Katsuma S, Daimon T, Horie S, Kobayashi M, and Shimada T., N-linked glycans of Bombyx mori nucleopolyhedrovirus fibroblast growth factor are crucial for its secretion, Biochemical and Biophysical Research Communications, 2006, 350, 1069-1075.
  85. Katsuma S, Horie S, Daimon T, Iwanaga M, and Shimada T., In vivo and in vitro analyses of a Bombyx mori nucleopolyhedrovirus mutant lacking functional vfgf, Virology, 2006, 355, 62-70.
  86. Herath CB, Ishiwata H, Shiojima S, Kadowaki T, Katsuma S, Ushizawa K, Imai K, Takahashi T, Hirasawa A, Takahashi S, Izaike Y, Tsujimoto G, and Hashizume K., Developmental aberrations of liver gene expression in bovine fetuses derived from somatic cell nuclear transplantation, Cloning and Stem Cells, 2006, 8, 79-95.
  87. Daimon T, Katsuma S, Kang W-K, and Shimada T., Comparative studies of Bombyx mori nucleopolyhedrovirus chitinase and its host ortholog, BmChi-h, Biochemical and Biophysical Research Communications, 2006, 345, 825-833.
  88. Katsuma S, Daimon T, Mita K, and Shimada T., Lepidopteran ortholog of Drosophila Breathless is a receptor for the baculoviral fibroblast growth factor, Journal of Virology, 2006, 80, 5474-5481.
  89. Daimon T, Katsuma S, Iwanaga M, Kang WK, and Shimada T., The BmChi-h gene, a bacterial-type chitinase gene of Bombyx mori, encodes a functional exochitinase that plays a role in the chitin degradation during the molting process, Insect Biochemistry and Molecular Biology, 2005, 35, 1112-1123.
  90. Katsuma S, Ruike Y, Yano T, Kimura M, Hirasawa A, and Tsujimoto G., Transcriptional regulation of connective tissue growth factor by sphingosine 1-phosphate in rat cultured mesangial cells, FEBS letters, 2005, 578, 2576-2582.
  91. Katsuma S, Hatae N, Yano T, Ruike Y, Kimura M, Hirasawa A, Tsujimoto G., Free fatty acids inhibit serum deprivation-induced apoptosis through GPR120 in a murine enteroendocrine cell line STC-1, Journal of Biological Chemistry, 2005, 280, 19507-19515.
  92. Yamada M*, Katsuma S*, Adachi T, Hirasawa A, Shiojima S, Kadowaki T, Okuno Y, Koshimizu T, Fujii S, Sekiya Y, Miyamoto Y, Tamura M, Yumura W, Nihei H, Kobayashi M, Tsujimoto G. (* contributed equally), Inhibition of protein kinase CK2 prevents the progression of glomerulonephritis, Proceedings of the National Academy of Sciences of the United States of America, 2005, 102, 7736-7741.
  93. Katsuma S, Hirasawa A, and Tsujimoto G., Bile acids promote glucagon-like peptide-1 secretion through TGR5 in a murine enteroendocrine cell line STC-1, Biochemical and Biophysical Research Communications, 2005, 329, 387-391.
  94. Katsuma S, Tanaka S, Omuro N, Takabuchi L, Daimon T, Imanishi S, Yamashita S, Iwanaga M, Mita K, Maeda S, Kobayashi M, and Shimada T., Novel macula-like virus identified in Bombyx mori cultured cells, Journal of Virology, 2005, 79, 5577-5584.
  95. Hirasawa A, Tsumaya K, Awaji T, Katsuma S, Adachi T, Yamada M, Sugimoto Y, Miyazaki S, Tsujimoto G., Free fatty acid regulate gut incretin glucagon-like peptide-1 secretion through GPR120, Nature Medicine, 2005, 11, 90-94.
  96. Takagaki K, Katsuma S, Horio T, Kaminishi Y, Tanaka T, Ohgi T, Yano J., Role of Chk1 and Chk2 in Ara-C-induced differentiation of human leukemia K562 cells., Genes to Cells, 2005, 10, 97-106.
  97. Iwanaga M*, Takaya K*, Katsuma S*, Ote M, Tanaka S, Kamita SG, Kang WK, Shimada T, and Kobayashi M. (* contributed equally), Expression profiling of baculovirus genes in permissive and nonpermissive cell lines, Biochemical and Biophysical Research Communications, 2004, 323, 599-614.
  98. Katsuma S, Tanaka S, Shimada T, and Kobayashi M., Reduced cysteine protease activity of the hemolymph of Bombyx mori larvae infected with fp25K-inactivated Bombyx mori nucleopolyhedrovirus results in the reduced postmortem host degradation, Archives of Virology, 2004, 149, 1773-1782.
  99. Katsuma S, Shimada T, and Kobayashi M., Characterization of the baculovirus Bombyx mori nucleopolyhedrovirus gene homologous to the mammalian FGF gene family, Virus Genes, 2004, 29, 211-217.
  100. Takagaki K, Katsuma S, Horio T, Kaminishi Y, Hada Y, Tanaka T, Ohgi T, Yano J., cDNA microarray analysis of altered gene expression in Ara-C-treated leukemia cells., Biochemical and Biophysical Research Communications, 2003, 309, 351-358.
  101. Katsuma S, Hada Y, Shiojima S, Hirasawa A, Tanoue A, Takagaki K, Ohgi T, Yano J, Tsujimoto G., Transcriptional profiling of gene expression patterns during sphingosine 1-phosphate-induced mesangial cell proliferation, Biochemical and Biophysical Research Communications, 2003, 300, 577-584.
  102. Shibata K, Katsuma S, Koshimizu T, Shinoura H, Hirasawa A, and Tsujimoto G., Alpha1-adrenergic receptor subtypes differentially control cell cycle of transfected CHO cells through a cAMP-dependent mechanism involving p27Kip1, Journal of Biological Chemistry. 2003, 278, 672-678.
  103. Katsuma S, Hada Y, Ueda T, Shiojima S, Hirasawa A, Tanoue A, Takagaki K, Ohgi T, Yano J, Tsujimoto G., Signalling mechanisms in sphingosine 1-phosphate-promoted mesangial cell proliferation, Genes to Cells. 2002, 7, 1217-1230.
  104. Katsuma S, Shiojima S, Hirasawa A, Suzuki Y, Ikawa H, Takagaki K, Kaminishi Y, Murai M, Ohgi T, Yano J, Tsujimoto G., Functional genomic search of G-protein-coupled receptors using microarrays with normalized cDNA library, Methods in Enzymology. 2002, 345, 585-600.

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