AE-Bio　東京大学農学生命科学研究科　生産環境生物学専攻 close


大門 高明


生産・環境生物学専攻
昆虫遺伝研究室


助　教

　略　歴
2002年　東京大学農学部卒業
2007年　東京大学大学院農学生命科学研究科博士課程修了

　研究概要
　カイコは古くから遺伝学の材料として用いられてきました。これまでに収集された突然変異系統の中には、休眠・眠性・化性・食性など、害虫防除の上でターゲットとなるだけでなく、生物学全体に大きなインパクトを与える、極めて重要な変異体が含まれています。ところが、カイコの分子遺伝学は大きく立ち遅れていたため、その豊富な遺伝資源は半ば手付かずの状態で残されてきました。
　そして近年、カイコの全ゲノム配列が決定されたことで、カイコの遺伝学は新たな局面を迎えようとしています。私は、ゲノム情報とトランスポゾンという強力な遺伝学的ツールを駆使して、休眠性・眠性・化性・食性といった鱗翅目昆虫に特有の生命現象に挑みたいと考えています。

　最近の研究成果
  1. Tsuguru Fujii, Takaaki Daimon, Keiro Uchino, Yutaka Banno, Susumu Katsuma, Hideki Sezutsu, Toshiki Tamura, and Toru Shimada (2010) Transgenic analysis of the BmBLOS2 gene that governs the translucency of the larval integument of the silkworm, Bombyx mori. Insect Molecular Biology (in press).
  2. Yan Meng, Susumu Katsuma, Takaaki Daimon, Yutaka Banno, Keiro Uchino, Hideki Sezutsu, Toshiki Tamura, Kazuei Mita, and Toru Shimada (2009) The silkworm mutant lemon (lemon lethal) is a potential insect model for human Sepiapterin reductase deficiency. Journal of Biological Chemistry 284(17): 11698 -11705.
  3. Susumu Katsuma, Tadashi Nakanishi, Takaaki Daimon, and Toru Shimada (2009) N-linked glycans located in the pro-region of Bombyx mori nucleopolyhedrovirus V-CATH are essential for the proper folding of V-CATH and V-CHIA. Journal of General Virology 90(1): 170-176.
  4. The International Silkworm Genome Consortium - Chinese group: Qingyou Xia, Jun Wang, Zeyang Zhou, Ruiqiang Li, Wei Fan, Daojun Cheng, Tingcai Cheng, Junjie Qin Jun Duan, Hanfu Xu, Qibin Li, Ning Li, Mingwei Wang, Fangyin Dai, Chun Liu, Ying Lin, Ping Zhaoa, Huijie Zhang, Shiping Liu, Xingfu Zha, Chunfeng Li, Aichun Zhao, Minhui Pan, Guoqing Pan, Yihong Shen, Zhihong Gao, Zilong Wang, Genhong Wang, Zhengli Wu, Yong Hou, Chunli Chai, Quanyou Yu, Ningjia He, Ze Zhang, Songgang Li, Huanming Yang, Cheng Lu, Jian Wang, and Zhonghuai Xiang, Japanese group : Kazuei Mita, Masahiro Kasahara, Yoichiro Nakatani, Kimiko Yamamoto, Hiroaki Abe, Brudrul Ahsan, Takaaki Daimon, Koichiro Doi, Tsuguru Fujiii, Haruhiko Fujiwara, Asao Fujiyama, Ryo Futahashi, Shin-ichi Hashimoto, Jun Ishibashi, Masafumi Iwami, Keiko Kadono-Okuda, Hiroyuki Kanamori, Hiroshi Kataoka, Susumu Katsuma, Shinpei Kawaoka, Hideki Kawasaki, Yuji Kohara, Toshinori Kozaki, Reginaldo M. Kuroshu, Seigo Kuwazaki, Kouji Matsushima, Hiroshi Minami, Yukinobu Nagayasu, Takao Nakagawa, Junko Narukawa, Junko Nohata, Kazuko Ohishi, Yukiteru Ono, Mizuko Osanai-Futahashi, Katsuhisa Ozaki, Wei Qu, Ladislav Roller, Shin Sasaki, Takuji Sasaki, Atsushi Seino, Masaru Shimomura, Michihiko Shimomura, Tadasu Shin-I, Tetsuro Shinoda, Takahiro Shiotsuki, Yoshitaka Suetsugu, Sumio Sugano, Makiko Suwa, Yutaka Suzuki, Shigeharu Takiya, Toshiki Tamura, Hiromitsu Tanaka, Yoshiaki Tanaka, Kazushige Touhara, Tomoyuki Yamada, Minoru Yamakawa, Naoki Yamanaka, Hiroshi Yoshikawa, Yang-Sheng Zhong, Toru Shimada and Shinichi Morishita (2008) The genome of a lepidopteran model insect, the silkworm Bombyx mori. Insect Biochemistry and Molecular Biology 38(12; Special Issue on the Silkworm Genome): 1036-1045.
  5. Ryo Futahashi*, Jotaro Sato*, Yan Meng*, Shun Okamoto, Takaaki Daimon, Kimiko Yamamoto, Yoshitaka Suetsugu, Junko Narukawa, Hirokazu Takahashi, Yutaka Banno, Susumu Katsuma, Toru Shimada, Kazuei Mita, and Haruhiko Fujiwara (2008) yellow and ebony are the responsible genes for the larval color mutants of the silkworm Bombyx mori. Genetics 180(4): 1995-2005. (* These authors contributed equally to this work)
  6. K P Arunkumar, Archana Tomar, Takaaki Daimon , Toru Shimada, and J Nagaraju (2008) WildSilkbase: An EST database of wild silkmoths. BMC Genomics 9: 338 (available online: http://www.biomedcentral.com/1471-2164/9/338/abstract).
  7. Takaaki Daimon, Tomohiro Taguchi, Yan Meng, Susumu Katsuma, Kazuei Mita, and Toru Shimada (2008) Beta-fructofuranosidase genes of the silkworm, Bombyx mori: Insight into enzymatic adaptation of B. mori to toxic alkaloids in mulberry latex. Journal of Biological Chemistry 283(22): 15271-15279.
  8. Shinpei Kawaoka, Susumu Katsuma, Takaaki Daimon, Ryoko Isono, Naoko Omuro, Kazuei Mita, and Toru Shimada (2008) Functional analysis of four Gloverin-like genes in the silkworm, Bombyx mori. Archives of Insect Biochemistry and Physiology 67(2): 87-96.
  9. Yan Meng, Naoko Omuro, Shunsuke Funaguma, Takaaki Daimon, Shinpei Kawaoka, Susumu Katsuma, and Toru Shimada (2008) Prominent down-regulation of storage protein genes after bacterial challenge in eri-silkworm, Samia cynthia ricini. Archives of Insect Biochemistry and Physiology 67(1): 9-19.
  10. Takaaki Daimon, Susumu Katsuma, WonKyung Kang, and Toru Shimada (2007) Functional characterization of chitinase from Cydia pomonella granulovirus. Archives of Virology 152(9): 1655-1664.
  11. Takaaki Daimon, Susumu Katsuma, and Toru Shimada (2007) Mutational analysis of active site residues of chitinase from Bombyx mori nucleopolyhedrovirus. Virus Research 124(1-2): 168-175.
  12. Susumu Katsuma, Takaaki Daimon, Satoshi Horie, Michihiro Kobayashi, and Toru Shimada (2006) N-linked glycans of Bombyx mori nucleopolyhedrovirus fibroblast growth factor are crucial for its secretion. Biochemical and Biophysical Research Communications 350(4): 1069-1075.
  13. Susumu Katsuma, Satoshi Horie, Takaaki Daimon, Masashi Iwanaga, and Toru Shimada (2006) In vivo and in vitro analyses of a Bombyx mori nucleopolyhedrovirus mutant lacking functional vfgf. Virology 355(1): 62-70.
  14. Takaaki Daimon, Susumu Katsuma, WonKyung Kang, and Toru Shimada (2006) Comparative studies of Bombyx mori nucleopolyhedrovirus chitinase and its host ortholog, BmChi-h. Biochemical and Biophysical Research Communications 345(2): 825-833.
  15. Susumu Katsuma, Takaaki Daimon, Kazuei Mita, and Toru Shimada (2006) Lepidopteran ortholog of Drosophila Breathless is a receptor for the baculoviral fibroblast growth factor. Journal of Virology 80(11): 5474-5481.
  16. Takaaki Daimon, Susumu Katsuma, Masashi Iwanaga, WonKyung Kang, and Toru Shimada (2005) The BmChi-h gene, a bacterial-type chitinase gene of Bombyx mori, encodes a functional exochitinase that plays a role in the chitin degradation during the molting process. Insect Biochemistry and Molecular Biology 35(10): 1112-1123.
  17. Manabu Ote, Kazuei Mita, Hideki Kawasaki, Takaaki Daimon, Masahiko Kobayashi, and Toru Shimada (2005) Identification of molting fluid carboxypeptidase A (MF-CPA) in Bombyx mori. Comparative Biochemistry and Physiology (Part B) 141(3): 314-322.
  18. Susumu Katsuma, Shinichiro Tanaka, Naoko Omuro, Lisa Takabuchi, Takaaki Daimon, Shigeo Imanishi, Shuichi Yamashita, Masashi Iwanaga, Kazuei Mita, Susumu Maeda, Masahiko Kobayashi, and Toru Shimada (2005) Novel macula-like virus identified in Bombyx mori cultured cells. Journal of Virology 79(9): 5577-5584.
  19. Takaaki Daimon, Koutaro Hamada, Kazuei Mita, Kazuhiro Okano, Masataka G. Suzuki, Masahiko Kobayashi, and Toru Shimada (2003) A Bombyx mori gene, BmChi-h, encodes a protein homologous to bacterial and baculovirus chitinases. Insect Biochemistry and Molecular Biology 33(8): 749-759.

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